421

421 stands for Kratom! 4/21 (April 21st) is national Kratom day. The day where you chug Kratom and get sauced/kratered (buzzed off kratom). Kratom gives you energy at lower doses and enhances mood and relaxation (especially at higher doses). Higher doses is also good for pain relief. Kratom can be taken at any time, but it's cooler to take it at 4:21pm.

Tom: I tried Kratom and I'm sauced! This 421 is great.

by CognitiveFuel December 18, 2022

421

National Surprise Drug Test Day

The day of 420
James: Bro i am so high right now

Phil: Be careful man tomorrow is national surprise drug test day! you know 421

by ExMar1n3G0n3C0p April 22, 2012

421

the day after 420

Remains Smokeout

many people still have shit from the day before, so on 421 they blaze up their remaining buds

Dude after 420 we can still blaze up on 421

by nicole April 21, 2004

421

The day following 420 (national potsmoking day)

a.k.a national munchies day

"WOOO HAPPY 4/20!!! *puffpuff*"

next day

"Pass the marshmallows and chex dammit!"

by Jbizz September 23, 2004

421

The day after 420, aka the day where everyone and everything comes down and waits for their massive high to burn off.

Hippie #1: Hey bud you wanna go cheef with me.
Hippie #2: Yeah sure dude, lets go smoke a fatty and we can giggle and poitless shit.
Hippie #1: Alright dude, lets go man.

by BuddahLovah April 23, 2005

421

drug combination:

lsd, followed one hour later with
mdma, followed four hours later with
2cb, and then maybe ketamine or pot after that kicks.

listed on bonus menu of 'when incubus attacks, vol 2' dvd
trouble in 421 is one of their early songs

Last night i went so deep inside trippin' the full 421...!

by chuckmullholland May 15, 2006

421

Dial code for Slovakia when you're calling from abroad.

420 should be Czech Republic. Not sure tho'.

Please dial [phone] for cheap poontang.

by Kamaho July 11, 2004