1 definition by IamUrban

to do something major, either something that can cause a huge disturbance or significance.
Manager: You ready for the audience?
Rapper: Yea, bout' to set it off mang.

or

(before attempting to rob a bank)
Criminal A: Let's do this.
Criminal B: Yea, lets set it off.
by IamUrban August 16, 2009
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