let's play some twayns...and then shine some sack
by jesse October 24, 2004
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Any song featuring both Lil' Wayne and T-Pain.
Boy: Dayum Who's this beat?
Girl: It's the new joint by Twayne.
by Danica G July 12, 2008
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The little bugs you find in your pubic hair
Dude, stop picking twaynes off your pubes
by hootmasterflex July 22, 2008
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the acronym of the name Tom Wayne. Twayne is annoying most times, all times actually , sometimes less than others. You can always count on twayne to be a good friend. He also gets mad pussy
Person 1) you see that little bitch right there?

Person 2) yeah, that’s twayne
by The one and only npc December 4, 2022
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