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Short for 'homophobic', spelt phonetically how it sounds.

Someone who hates/fears homosexuality or homosexuals.
John: Did you hear, Matt's gay! That's so gross.
Luke: Hey man, don't be such a hofo.
Hofo by crayolaxsunshine April 15, 2010
Related Words
n. Derived from mofo (motherfucker), it can used used to describe someone who has sex with prostitutes.

Also, can be used to describe someone who has sex with someone whose first name begins with Ho-
"You hear about Rob and Holly?"
"Yeah. Rob is such a hofo"
hofo by Crabsoneyes January 6, 2005
homo+mofo=hofo
i.e florin's a hofo
hofo by Anonymous February 4, 2003
Ones collection/portfolio of girl's phone numbers. One's hofolio is often stored on their cellular phone.
"Who should we hang out with tonight? You should check your hofolio to see who is available."
Hofolio by Angstd May 16, 2008

ho fo sho 

When you are quite certain a woman is of whorish descent.

hoforganist 

hey let’s go hoforganist

another meaning for

“hey let’s go north mall”

which means

“sex?”
hoforganist by sex, north mall January 16, 2021