Like the insult grow a pair, only said to a girl acting particularly manly or that looks like a man. Also used to just make one mad.
Jane: Shut up Bob you know I'm strong and can beat up guys!
Bill: Wow Jane, how about you lose a pair and act like a girl!

Bob: Hey Kate! Lose a pair!
by Johnny Locke April 19, 2010
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An alternate description of the term shart. An unintentional emission of feces during intended flatulence.
I was taking a piss the other day and tried to fart. It sucked, dude--I totally lost the gamble!
by bscepter February 12, 2005
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-Usually found on tatoos it means a guys got bad luck and/or hes a guy whos been through a lot.
-Can be used for white trash or middle class who know they started life without a chance.
Q: "Life sucks man."
A: "Yeah well we were born to lose"
by That kid you hated November 18, 2004
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loosing your sexual arousal (totally independent of gender), because f.e. the object of desire talk to much or is doing something, that is killing your vibe.
Stella: *starts kissing Ted*
Ted: *not kissing her* "George Lucas based the film's structure on Akira Kurosawa's The Hidden Fortress. He also owes a debt to Campbell's work with comparative mythology."
Stella: "Yeah, Ted, I'm losing wood over here. What's going on?"
by z4kk February 2, 2017
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Someone who always wins due to the combination of luck, swagger, higher education, better job, hotter boyfriend/girlfriend etc. People are insanely jealous of them in general.
I always comes out on top, no matter what. Never Lose.
by Keef_the_Dutchman October 21, 2010
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