ignorance
Willful lack of knowledge: An seemingly small nuisance that is secretly the greatest problem in modern civilization. It has been used to justify some of the greatest atrocities humanity has ever committed, stunt and void necessary advances and progress on all fronts, and suppress the rights and opinions of others by no reasonable fault on their part. It is an all-encompassing ideology that spans most if not all of society in one way or another, whether it be small ideas like "It's just a (insert item here)." or major global historic events like the Trail of Tears; and if left unchanged will eventually be the downfall of mankind.
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