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Someone who is a slut,whore, tramp, or turns trics. Referring mostly to females. She openly appears as a slut and is very forward in the way she approaches a male. She mostly performs sexual deeds for males and brags about it.

(origin: Philly particularly in the North East area)
That girl you're dating is such a tweeker. She slept with Jerome John and Darryl in one night.
Tweeker by UD Girl 116 August 12, 2009
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Someone that you date for only two weeks
Aaron: are you still dating sarah?
Matt: no, she was a tweeker.
tweeker by banana rammer April 27, 2011
a krunck non-sleepin,but hell yea be eatin who likes to twist tha pizzy fa shizzy my nizzy. Tha fool cleans betta than Mr. Clean. Ya got a new best friend cause they speak nothin but tha truth in tha end. Maybe bad and u may get sad, but while ur tweekin u aint nothing but glad. And you see them still seekin....and thats the definition of tweekin.
That Tweeker Rox!!
tweeker by Queen Tweeker January 25, 2004
A small rock protuberance used as a hand hold or foot hold when climbing a rock face.
I was hanging on a tweekers when my foot slipped and I fell.
Tweeker by rock-a-jock-a-man December 13, 2008
a tweeker is someone acting like a retard. constantly flipping out over stupid shit. just plain fucking annoying.
The lady that works at the register was being a tweeker because the credit card was too close to the register.
tweeker by used4life September 2, 2005
"hey, how about that Tim Jeager?"

"what a Tweeker"
tweeker by Tims mom March 27, 2004
A tiny protubrance used to support one's body weight when rock climbing.
I was standing a tweeker, but my foot slipped and I then fell.
Tweeker by rock-a-jock-man March 12, 2008