1)A male who masturbates frequently

2)Someone who sucks at everything they have ever tried.
1)That kid has been in his room alone all day. What a tweaker!

2)He is such a tweaker he should give up school and start giving handjobs for crack!
by UOIT shredderz January 20, 2005
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a tweaker is simply a weirdo, from that weird girl who stalks you, the weird witch lady who lives at number 3 to that crazy old guy with the massive beard who rides his bike around all day muttering. its useful to have in the vocab as it can be shouted with no risk of insult to the tweaker in question. by streachin the sylables it can be made into an almost bird like cry. if u like
tweeeeee-kaaaaaahh
"oh my god, this guy is a fucking stalker, what a tweaker"

"shit dude, did you see that matey wearin girls clothes, what a tweeker"

"whos that tweaker on a microscooter"
by purv of the gore April 26, 2007
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A man or a female who jump at loud noises or are always freaked out by little things
"Holy shit Tim just totally tweaked at the car that passed by us, what a tweaker!"
by Diggyer November 8, 2005
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Some one who twitters too frequently
Wow your sister is such a tweaker, I mean she has like 87 posts a day.
by BeanyStiney April 8, 2009
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Keeth, Johnny Ray and Tim. Not Tweaker Dave any more.
Keeth, Johnny Ray and Tim are fucking tweakers but Tweaker Dave isn't a tweaker anymore.
by Kevin Twisted April 9, 2005
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"Where's Hayden? Is he running late?"
"I don't know, I'll send him a tweaker and find out where he is."
by Religioo January 16, 2010
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