When you have become so tired of something/someone, that it is making you sick. Something that mothers often say to their misbehaving, ill-mannered children.
Mother: Tony, I am so sick 'n tired of your shit lying all over, that it has made me sick to the point of vomiting in last nights casserole. I just dressed it with ketchup, so fuck you!
by Zob Rombie June 30, 2016