VTA Line 22, a bus route that goes between Menlo Park and eastern San Jose (more specifically, Eastridge Mall) along El Camino Real, The Alameda, Santa Clara Street, Alum Rock Avenue, King Road, and Tully Road. It is one of the longest and most well-known bus routes in the South Bay region of the San Francisco Bay.

The 22 runs more frequently than any other bus route--buses show up every 10-15 minutes during the day, and the route operates 24/7. Additionally, it is the only bus route that uses bendy buses.

Unfortunately, because of the 24/7 schedule, bums and smells reminiscent of shit are pretty common, especially at night. As a result, the 22 has come to be known as "Hotel Deuce Deuce," "the Felon Express," among others.
I stepped onto the 22, and got out in 3 seconds flat. I'd rather take a cab home.
by Raymoo October 17, 2007
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The birthday that you've been waiting for because you want to use Taylor Swift's lyrics "I don't know about you, but I'm feeling 22"
"I'm posting a pic from my birthday party, what caption should I put ?"

"maybe "I don't know about you but im feeling 22" ?"
"bro that was a trend in 2013"
by elderwand December 20, 2020
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When one of your friends is so messed up that he is no longer known as a person, so is now called by a number.
Damn look at 22!! i cant believe hes rolling around in his puke.
by dotrat93 May 22, 2011
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1)hate / hating
2) haters (22's)
1) I 22 dat girl
2) there are 22's in da joint
by Boots April 16, 2005
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A is smoking a joint
B wanna smoke
-B: "22"
-A: Here!
And B gets the joint (theoretically)
by areyoucopsorwhat August 24, 2003
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Big balla occasionally a homosexual male if ya know what i mean?
I 22'd some guys nutz
by Bob. April 11, 2005
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A common caliber of rim-fire weapons. This is often thought to be an ineffective caliber by people who cannot hit what they are aiming at. Used properly, it can be extremely fatal, especially with high-velocity ammunition.
The burglar died from a single shot to the head from a .22 pistol.
by BlastMaster May 17, 2003
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