The first definition already listed is accurate as to the meaning and general composition:

-Promethazine
-Codeine syrup
-Any clear soda (often fruit flavored)
-One or more Jolly Ranchers for flavor

There are many variations and differing usage, but in order to be considered true and unadulterated sizzurp, the above ingredients are necessary.

The likely etymology is from the word "syrup", pronounced with a Southern accent like "surrup", or just "surp" when spoken loosely. Ebonified with "-izz" (like hizzouse to mean house), forms "sizzurp".
by LVXseeker November 6, 2010
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Promethazine Codiene Mix with
Smirnoff Ice

Jolly Ranchers or Shark Gummy Worms

Fucks you up but will give you the biggest kottonmouth.
by haroldilee September 10, 2011
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According to A Hip Hop Dictionary -my only source at the time. Three-Six-Mafia intended Sizzurp to be...

1. Cough syrup (containg dextromorphan)
2. Vodka
3. Milk of Magnesia (..>?)

Different types of this have been shown, but this is the "Sippin on some sizzurp" kind.
Sip, Sippin on some Sizzurp - Triple 6 Mafia
by Matt McDaniel April 16, 2006
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Sizzurp is cough medican which has codeine in it, users mix it with many drinks mostly Sprite, the effect of Purple Sizzurp are being tired and feeling like the body is leaning to one side. other names for this drink are, sizzurp, syrup, lean\

this is mostly known because of artist like, lil wayne, chief keef and soulja boy
person 1 : pour up that purple sizzurp
person 2: im so lean right now
by Chief Purple September 15, 2013
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A drink that originated in Houston, Texas. It consists of purple cough syrup (Promethazine with Codeine), and Sprite (or other soft drink) and a Jolly Rancher. Usually consumed while listening to chopped and screwed rap music (ie. Paul Wall, Mike Jones, DJ Screw).
We be sippin tha purple syrup or sizzurp n get hella lean.
by Van-Skip May 31, 2006
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(n) alcoholic beverage consisting of peach schnapps and Sizzurp

This variation of the Fuzzy Navel (peach schnapps and orange juice) is suited for any trendy urban female.
Hey Lil Wayne, when you're at the club sipping on some Promethazine with Codeine syrup, why don't you order your fine lady a Fuzzy Sizzurp?
by fuzzysizzurpplz June 4, 2009
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Its Human Resources BS at its worst, generally served for free at career fairs at a variety of universities all across America. Examples of "dat HR sizzurp" include: offers of opportunities to work abroad, face to face client meetings, words such as strategy and management and opportunities for development. These things never happen at your entry level position or internship, but are commonly discussed at said career fairs.

Dat sizzurp is generally so strong that it can only be sipped, and seems great while your leanin' on it. It is highly intoxicating. Generally, once one's career at said firm begins, the user soon realizes that the HR sizzurp is a terrible concoction with horrific side effects.

See Also: The HR Koolaid, a term commonly used on "GettingDrunkinFirstClass.com".
White Privileged Kid: "All John talks about is his new job at Management Consulting Firm X, but he's yet to find out that on the job, he'll just be making Powerpoints all day."

Other White Privileged Kid: "Yeah he's still leanin' on dat HR sizzurp."
by FratStein July 20, 2009
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