1. To be under the effects of amphetamines, esp. crystal methamphetamine hydrochloride.

2. To be nervous or worried about something, esp. the presence of law-enforcement personnel.
1. Dude I took a fat hit of some dank ice and I'm tweaking balls!

2. Dude I got pulled over with an o in my glove compartment and I was tweaking balls!
by Bri90 January 28, 2010
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To do crack or act like doing crack/cocaine.

Most of the time used in a question
"Gave who some dam money? I aint gave no nobody no damn money girl! IS YOU TWEAKING!?" By R-kelly Real Talk
by HondaKiller2TGR June 19, 2008
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A crack head in withdrawal after being denied a dollar from a stranger
That white boy over there tweaking because I wouldn’t give him a dollar
by jmusic January 30, 2020
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Starting unnecessary problems or arguments. Usually about a certain action of yours or as a response to something you said. Or even about something unrelated to you.
Hey, so you still down to go out tonight?” Molly
“Dang, hold on. My girlfriend just started tweaking about how the living room is a mess.”
by Batman in 2006 August 20, 2021
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