Being just the slightest bit off. Having a clumsy way about it.
" That squirrel is running sideways, he's pretty derpy."

" Kristen Stewart's facial expressions are so derpy, it's painful to watch."
by UnicornPornHorn March 29, 2015
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Clumsy or uncoordinated; prone to cause accidents likely due to some, often humourous, mental lapse.
Ugh, I feel so derpy today. I just filled the coffee maker with pencil shavings and tried to write something down with a coffee bean.
by Count Hieronymus Schlick March 22, 2012
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Not "all there in the head"; possibly lacking intelligence or common sense. The wall-eyed background character in "My Little Pony: Friendship is Magic", Derpy Hooves, is named after this.
Hey, look at that guy sticking his aluminum foil-wrapped dick into an electrical outlet. That's derpy if I've ever seen it.

Derpy is best pony.
by datSato January 1, 2012
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Derpies is an increasingly prevalent socially-transmitted disease that impairs mental function in afflicted individuals. Derpies has become as common as one-in-two individuals on average in the world's population. The level of concentration of affected individuals increases the risk of exposure and transmission exponentially. Despite this fact, rural areas appear equally affected as urban areas. Cooperative vigilance and increased awareness are strongly advised as the only effective deterrents to the spread of this illness.

Symptoms of Derpies include:

Decline in common sense
Impairment of motor functions
Reduction in observational skills
Appreciation of reality television
Pattern of poor decisionmaking
Increased laugh response
Reckless driving and parking
Misuse of commonly used words
Distortion of spacial reasoning
Excessive quasi-aggressive
physical contact

If four or more of the listed symptoms apply to you, a friend or a loved one, Derpies may have already taken root in your social environment. Unlike its permanent, sexually-transmitted
cousin; Herpes, the non-permanent Derpies is potentially deadly. It is important for affected individuals to seek academic assistance immediately to mitigate Derpies-associated
risks to your social well-being.
Bob: "John has been acting ridiculously. He likes stupid things and laughs all the time."
Alice: "He has been hanging out with Frat boys."
Bob: "He has been watching the Jersey Shore reruns."
Alice: "We need to have an talk with him. I think that he has Derpies. And, I don't want to get it to."
by PacketLost July 15, 2015
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A disease (perhaps contagious) symptomized by using continuous "derp" actions.
"Man, I think Micheal has derpies."
"I know a few people who certainly have derpies."
by Lsh14 April 27, 2010
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A pony that is from My Little Pony
I watched My Little Pony and my favorite pony is Derpy
by Cat Lover50 October 18, 2015
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